The Roles of NDR Protein Kinases in Hippo Signalling
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چکیده
منابع مشابه
The Roles of NDR Protein Kinases in Hippo Signalling
The Hippo tumour suppressor pathway has emerged as a critical regulator of tissue growth through controlling cellular processes such as cell proliferation, death, differentiation and stemness. Traditionally, the core cassette of the Hippo pathway includes the MST1/2 protein kinases, the LATS1/2 protein kinases, and the MOB1 scaffold signal transducer, which together regulate the transcriptional...
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Regulation of Hippo signalling by p38 signalling
The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats. Here we identify the p38 mitogen-activated protein kinase (MAPK) pathway as a new upstr...
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ژورنال
عنوان ژورنال: Genes
سال: 2016
ISSN: 2073-4425
DOI: 10.3390/genes7050021